In Vivo Skin Solvent Penetration Measurements Using Opto-thermal Radiometry and Fingerprint Sensor
This latest study on in vivo transdermal drug delivery by using opto-thermal radiometry and a capacitance-based fingerprint sensor is presented. A small amount of solvent was applied on the test sites of a volar forearm for a few minutes; opto-thermal measurements and fingerprint sensor measurements...
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Veröffentlicht in: | International journal of thermophysics 2012-11, Vol.33 (10-11), p.1787-1794 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | This latest study on
in vivo
transdermal drug delivery by using opto-thermal radiometry and a capacitance-based fingerprint sensor is presented. A small amount of solvent was applied on the test sites of a volar forearm for a few minutes; opto-thermal measurements and fingerprint sensor measurements were performed both before the solvent application and periodically after. The results showed that, by selecting different detection wavelengths, opto-thermal radiometry could give the information either on the water concentration within skin or the solvent concentration within skin. The capacitance-based fingerprint sensor could clearly visualize solvent penetration through
in vivo
human skin, as it generated dynamic two-dimensional (2D) images of solvent distribution within skin, and combining with tape stripping, it was also possible to get solvent 3D depth profiles within skin. The correlation between opto-thermal transient emission radiometry and fingerprint sensor measurements was also evaluated. |
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ISSN: | 0195-928X 1572-9567 |
DOI: | 10.1007/s10765-012-1318-6 |