One-pot synthesis of aryl(hetaryl)-thiazolylphthalazine-1,4-diones via a multicomponent approach

An expeditious one-pot synthesis has been developed to obtain aryl(hetaryl)-substituted thiazolylphthalazine-1,4-diones via a multicomponent approach. The reaction of phenacyl bromides with thiosemicarbazide and phthalic anhydride afforded arylthiazolylphthalazine-1,4-diones. The reaction of 3-(2-bromoacetyl)coumarins with thiosemicarbazide and phthalic anhydride afforded hetaryl-containing 2-thiazolylphthalazine-1,4-diones under the same reaction conditions in excellent yields. The structures of all the synthesized compounds were confirmed by their analytical and spectral data.