Synthesis and properties of 6,6-di(indol-3-yl)-indolo[2,1-b]quinazolin-12(6H)-one and its 2,8-dimethyl and 2,8-dibromo derivatives

Synthesis and properties of 6,6-di(indol-3-yl)-indolo[2,1-b]quinazolin-12(6H)-one and its 2,8-dimethyl and 2,8-dibromo derivatives

The condensation of tryptanthrin, as well as its 2,8-dimethyl and 2,8-dibromo derivatives with indole gave previously unreported 6,6-di(indol-3-yl)indolo[2,1- b ]quinazolin-12(6 H )-ones. 2,8-Disubstituted tryptanthrins and 6,6-di(indol-3-yl)indolo[2,1- b ]quinazolin-12(6 H )-one were shown to inhib...

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2013-06, Vol.49 (3), p.452-456
Hauptverfasser: Moskovkina, T. V., Kalinovskii, A. I., Martyyas, E. A., Anisimov, M. M.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Organic Chemistry
Pharmacy
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Zusammenfassung:The condensation of tryptanthrin, as well as its 2,8-dimethyl and 2,8-dibromo derivatives with indole gave previously unreported 6,6-di(indol-3-yl)indolo[2,1- b ]quinazolin-12(6 H )-ones. 2,8-Disubstituted tryptanthrins and 6,6-di(indol-3-yl)indolo[2,1- b ]quinazolin-12(6 H )-one were shown to inhibit Candida albicans KMM 455. Solutions of tryptanthrin itself and its 6,6-diindolyl derivative upon the absorption of light at 434 and 340 nm exhibited fluorescence maxima at λ max 525 and 500 nm, respectively.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-013-1267-4