Efficient solid-phase synthesis of isocytosine derivatives

Efficient solid-phase synthesis of isocytosine derivatives

We have investigated the potential use of a solid-phase synthesis of novel 6-(arylmethyl)-5-methyl-isocytosine derivatives based on the immobilization of the corresponding 2-thiothymine on a Merrifield resin, oxidation of the immobilized form to the sulfone, and aminolysis of the latter under mild c...

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2009-11, Vol.45 (11), p.1365-1369
Hauptverfasser: Novakov, I. A, Orlinson, B. S, Brunilin, R. V, Nawrozkij, M. B, Gordeeva, E. A, Savel‘ev, E. N, Gerasimov, E. N
Format: Artikel
Sprache:eng
Schlagworte:
antiviral properties
Chemistry
Chemistry and Materials Science
isocytosines
Organic Chemistry
Pharmacy
solid-phase synthesis
“addition-elimination” mechanism
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Beschreibung
Zusammenfassung:We have investigated the potential use of a solid-phase synthesis of novel 6-(arylmethyl)-5-methyl-isocytosine derivatives based on the immobilization of the corresponding 2-thiothymine on a Merrifield resin, oxidation of the immobilized form to the sulfone, and aminolysis of the latter under mild conditions.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-010-0434-0