Synthesis and functionalization of the 3-(1,3,4-oxadiazol-2-yl)-1h-indoles

A modified method is proposed for the preparative synthesis of 3-(1,3,4-oxadiazol-2-yl)-1H-indoles in high yield. We are the first to demonstrate the functionalization of this heterocyclic system by alkylation. In particular, syntheses are reported for [3-(1,3,4-oxadiazol-2-yl)-1H-indol-1-yl]acetic...

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Veröffentlicht in:	Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2009-10, Vol.45 (10), p.1270-1275
Hauptverfasser:	Alyab'ev, S. B, Kravchenko, D. V, Ivashchenko, A. V
Format:	Artikel
Sprache:	eng
Schlagworte:	3-(1,3,4-oxadiazol-2-yl)-1H-indoles [3-(1,3,4-oxadiazol-2-yl)-1H-indol-1-yl]acetic acids amide library Chemistry Chemistry and Materials Science intramolecular cyclization Organic Chemistry orthoesters Pharmacy
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Beschreibung
Zusammenfassung:	A modified method is proposed for the preparative synthesis of 3-(1,3,4-oxadiazol-2-yl)-1H-indoles in high yield. We are the first to demonstrate the functionalization of this heterocyclic system by alkylation. In particular, syntheses are reported for [3-(1,3,4-oxadiazol-2-yl)-1H-indol-1-yl]acetic acids and their amide derivatives.
ISSN:	0009-3122 1573-8353
DOI:	10.1007/s10593-010-0418-0