Synthesis of 2-aroyl-1-hydroxy-4,5-dimethylimidazoles by reaction of 3-hydroxyamino-2-butanone oxime with arylglyoxals

Treatment of the acetate of 3-hydroxyamino-2-butanone oxime with arylglyoxals gives α-aroylnitrones which cyclize under acid catalyzed conditions to form principally 2-aroyl-1-hydroxy-4,5-dimethyl-imidazoles. An X-ray structural analysis of 2-benzoyl-1-hydroxy-4,5-dimethylimidazole has been carried...

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Veröffentlicht in:	Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2009-06, Vol.45 (6), p.691-697
Hauptverfasser:	Amitina, S. A, Tikhonov, A. Ya, Grigor'ev, I. A, Gatilov, Yu. V, Selivanov, B. A
Format:	Artikel
Sprache:	eng
Schlagworte:	2-aroyl-1-hydroxyimidazoles arylglyoxals Chemistry Chemistry and Materials Science hydroxylamino oxime Organic Chemistry Pharmacy pyrazine 1,4-dioxides X-ray structural analysis α-aroyl nitrones
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Beschreibung
Zusammenfassung:	Treatment of the acetate of 3-hydroxyamino-2-butanone oxime with arylglyoxals gives α-aroylnitrones which cyclize under acid catalyzed conditions to form principally 2-aroyl-1-hydroxy-4,5-dimethyl-imidazoles. An X-ray structural analysis of 2-benzoyl-1-hydroxy-4,5-dimethylimidazole has been carried out.
ISSN:	0009-3122 1573-8353
DOI:	10.1007/s10593-009-0329-0