Reaction of 2-alkylthio-6-amino-pyrimidin-4(3H)-ones with ethyl bromopyruvate. Synthesis of furo-[2,3-d]-pyrimidine and furo[3,2-e]imidazo-[1,2-c]pyrimidine carboxylates

Reaction of 2-alkylthio-6-aminopyrimidin-4(3H)-ones with ethyl bromopyruvate to give ethyl 2-alkyl-thio-4-aminofuro[2,3-d]pyrimidine-5-carboxylates has been shown to proceed under neutral or acidic conditions. The obtained furo[2,3-d]pyrimidines underwent further cyclocondensation reaction with ethy...

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Veröffentlicht in:	Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2009-03, Vol.45 (3), p.357-360
Hauptverfasser:	Masevicius, V, Petraityte, G, Tumkevicius, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Chemistry and Materials Science cyclization furo[2,3-d]pyrimidines furo[3,2-e]imidazo[1,2-c]pyrimidines Organic Chemistry Pharmacy pyrimidin-4(3H)-ones
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Zusammenfassung:	Reaction of 2-alkylthio-6-aminopyrimidin-4(3H)-ones with ethyl bromopyruvate to give ethyl 2-alkyl-thio-4-aminofuro[2,3-d]pyrimidine-5-carboxylates has been shown to proceed under neutral or acidic conditions. The obtained furo[2,3-d]pyrimidines underwent further cyclocondensation reaction with ethyl bromopyruvate to afford diethyl 5-alkylthiofuro[3,2-e]imidazo[1,2-c]pyrimidine-2,9-dicarboxy-lates.
ISSN:	0009-3122 1573-8353
DOI:	10.1007/s10593-009-0264-0