Positional isomers of thienopyrimidinones

Positional isomers of thienopyrimidinones

Condensation of o-cyanomethylbenzoic acids with esters of 2-aminothiophene-3-carboxylic and 3-amino-thiophene-2-carboxylic acids to give isomeric 2-(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-ylmethyl)-benzoic acids and their ethyl and phenacyl esters. Methylation of esters occurs at N-3. The spectro...

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2008-06, Vol.44 (6), p.750-758
Hauptverfasser: Kucherenko, T. T, Zadorozhny, A. V, Kovtunenko, V. A
Format: Artikel
Sprache:eng
Schlagworte:
4-oxopyrimidinones
Chemistry
Chemistry and Materials Science
Organic Chemistry
Pharmacy
thienopyrimidinones
thiophenes
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Beschreibung
Zusammenfassung:Condensation of o-cyanomethylbenzoic acids with esters of 2-aminothiophene-3-carboxylic and 3-amino-thiophene-2-carboxylic acids to give isomeric 2-(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-ylmethyl)-benzoic acids and their ethyl and phenacyl esters. Methylation of esters occurs at N-3. The spectroscopic characteristics of the positional isomers are compared at the level of carboxylic acids, their esters, and methylated products.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-008-0100-y