Investigation of the conformational transformations in some 7α-methyl-6-oxa-14β-analogs of steroidal estrogens by NMR spectroscopy

The stereochemical structure and conformational transformations of two 6-oxa-14β-estra-1,3,5(10), 8(9)-tetraenes having an α-methyl group at position 7 were investigated. It was found that the substituent at the C-17 atom has an effect on the formation of the conformers in solution. In the analog co...

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Veröffentlicht in:	Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2008-06, Vol.44 (6), p.654-665
Hauptverfasser:	Selivanov, S. I, Morozkina, S. N, Chentsova, A. S, Shavva, A. G
Format:	Artikel
Sprache:	eng
Schlagworte:	6-oxa-14β-analogs of steroidal estrogens Chemistry Chemistry and Materials Science conformational equilibria nuclear magnetic resonance spectroscopy Organic Chemistry Pharmacy
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The stereochemical structure and conformational transformations of two 6-oxa-14β-estra-1,3,5(10), 8(9)-tetraenes having an α-methyl group at position 7 were investigated. It was found that the substituent at the C-17 atom has an effect on the formation of the conformers in solution. In the analog containing a C-17 keto group in solution there are two conformers, whereas the 17α-acetoxy derivative has only one conformer.
ISSN:	0009-3122 1573-8353
DOI:	10.1007/s10593-008-0091-8