Effect of 5-HT2A Receptor Antagonists on Blood Flow in the Carotid Vessels upon Elevation of Serotonin Level

We studied the ability of predominantly 5-HT 2A receptor antagonists to prevent a serotonin-induced change of blood flow in the carotid vessels of rats with experimental serotonin-induced spasm. Ritanserin, ketanserin, and 5-HT 2A receptor antagonist RU-476 reduced the effect of serotonin on the blo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of experimental biology and medicine 2014-07, Vol.157 (3), p.350-352
Hauptverfasser:	Yakovlev, D. S., Spasov, A. A., Mal’tsev, D. V., Anisimova, V. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Cell Biology Internal Medicine Laboratory Medicine Pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We studied the ability of predominantly 5-HT 2A receptor antagonists to prevent a serotonin-induced change of blood flow in the carotid vessels of rats with experimental serotonin-induced spasm. Ritanserin, ketanserin, and 5-HT 2A receptor antagonist RU-476 reduced the effect of serotonin on the blood fl ow velocity in the internal carotid artery by 2.3, 1.7, and 2.6 times, respectively.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-014-2563-4