Hypoglycemic Effects of Hyaluronate-Endo-β-NAcetylhexosaminidase Immobilized by Electron Beam Synthesis Nanotechnology

Hypoglycemic Effects of Hyaluronate-Endo-β-NAcetylhexosaminidase Immobilized by Electron Beam Synthesis Nanotechnology

Hypoglycemic effect of hyaluronate-endo-β-N-acetylhexosaminidase immobilized by electron-beam synthesis nanotechnology (imHEA-HA) was studied in experimental insulindependent and insulin-independent diabetes mellitus. The drug exhibited a hypoglycemic effect of its own and potentiated the pharmacolo...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2012-05, Vol.153 (1), p.94-97
Hauptverfasser: Dygai, A. M., Zyuz’kov, G. N., Zhdanov, V. V., Udut, E. V., Miroshnichenko, L. A., Khrichkova, T. J., Simanina, E. V., Stavrova, L. A., Gurto, R. V., Minakova, M. Yu, Chajkovskij, A. V., Markova, T. S., Artamonov, A. V., Bekarev, A. A., Madonov, P. G., Kinsht, D. N.
Format: Artikel
Sprache:eng
Schlagworte:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Internal Medicine
Laboratory Medicine
Pathology
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Zusammenfassung:Hypoglycemic effect of hyaluronate-endo-β-N-acetylhexosaminidase immobilized by electron-beam synthesis nanotechnology (imHEA-HA) was studied in experimental insulindependent and insulin-independent diabetes mellitus. The drug exhibited a hypoglycemic effect of its own and potentiated the pharmacological effect of exogenous insulin injected in vivo . Studies on liver cell culture demonstrated an increase of cell sensitivity to insulin after treatment with imHEA-HA.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-012-1652-5