Study of High-Resolution H1 Nuclear Magnetic Resonance Spectra of the Serum and Its Albumin Fraction in Patients with the First Schizophrenia Episode

Study of High-Resolution H1 Nuclear Magnetic Resonance Spectra of the Serum and Its Albumin Fraction in Patients with the First Schizophrenia Episode

We studied high-resolution 1 H nuclear magnetic resonance spectra of the serum and serum albumin from patients with the fi rst episode of schizophrenia and healthy individuals. A relative increase in signal intensities of CH 2 protons in serum LDL and VLDL in schizophrenia was demonstrated. Higher i...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2012-04, Vol.152 (6), p.748-751
Hauptverfasser: Babushkina, T. A., Klimova, T. P., Peregudov, A. S., Gryzunov, Yu. A., Smolina, N. V., Dobretsov, G. E., Uzbekov, M. G.
Format: Artikel
Sprache:eng
Schlagworte:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Experimental Methods for Clinical Practice
Internal Medicine
Laboratory Medicine
Pathology
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Zusammenfassung:We studied high-resolution 1 H nuclear magnetic resonance spectra of the serum and serum albumin from patients with the fi rst episode of schizophrenia and healthy individuals. A relative increase in signal intensities of CH 2 protons in serum LDL and VLDL in schizophrenia was demonstrated. Higher intensities of CH 2 and CH 3 protons of non-esterifi ed fatty acids were found in 1 H nuclear magnetic resonance spectra of serum albumin. These data attest to an essential role of changes in lipid metabolism and changed ligand load of albumin in schizophrenia.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-012-1622-y