Analysis of Vinyl Chloride in Vapor Phase of Mainstream Cigarette Smoke by GC–MS Under ISO and Health Canada Intensive Machine Smoking Regimens

Vinyl chloride (VC) in the vapor phase of mainstream cigarette smoke was determined under both International Organization for Standardization (ISO) and Health Canada intensive (HCI) machine smoking regimens, which was suspected to be carcinogenic compound. VC was collected by passing the mainstream cigarette smoke through a Cambridge Filter Pad (CFP) into cryogenic traps containing methanol. The impinger solutions were fortified with VC- d 3 and analyzed by GC–MS. Limits of detection for vinyl chloride was 0.9 ng mL −1 with the recovery in the range of 93.2–98.4 %. Moreover, the intra-day and inter-day precision was 7.39 and 9.77 %, respectively. Under HCI machine smoking regimen, the vinyl chloride yields in vapor phase of mainstream cigarette smoke were much higher and the average increase was greater than 100 % compared with those under ISO smoking condition.