Chinese experts＇ consensus on diagnosis, prevention, and treatment of chemotherapy-induced hepatotoxicity

Overview Drug-induced liver injury （DILI） due to acetamino- phen overdose and idiosyncratic drug reactions usually occurs 5-90 days after exposure to the causative drug. Ninety percent of DILI cases are acute. As one of the most common non-infectious liver diseases, DILI represents a growing challenge for clinicians. According to data from WHO , DILI is the fifth leading cause of liver disease mortality. In China, DILI accounts for 1%-5% of hospitalized patients with liver diseases, 10% of patients with acute hepatitis, and 12.2% of patients with fulminant hepatitis .