Electrochemical behavior of tadalafil on TiO2 nanoparticles–MWCNT composite paste electrode and its determination in pharmaceutical dosage forms and human serum samples using adsorptive stripping square wave voltammetry

A sensitive and selective electroanalytical method for the determination of tadalafil (TAD) using adsorptive stripping square wave voltammetry at multiwalled carbon nanotube paste electrode (MWCNTPE) and modified TiO 2 -multiwalled carbon nanotube paste electrode (TiO 2 -MWCNTPE) was presented. The calibration curves were linear in the concentration range of 3.6–8.1 and 12.7–61.1 μM on MWCNTPE, 0.27–15.2 μM on TiO 2 -MWCNTPE. The recommended method was successfully applied to the determination of the drug in tablets and human serum samples with good recoveries. The selectivity of the proposed method was considered in the presence of Ca 2+ , K + , Na + , 2-mercapto benzimidazole, thiourea, and dopamine by means of recovery tests. Interfering agents did not show considerable effect on TAD determination. No electroactive interferences from the tablet excipients and endogenous substances from biological material were detected. The possible electrooxidation pathway and the number of transferred electrons were also investigated.