1,ω-Bis(formylphenoxy)alkane: versatile precursors for novel bis-dihydropyridine derivatives

1,ω-Bis(formylphenoxy)alkane: versatile precursors for novel bis-dihydropyridine derivatives

Reaction of β -aminocrotonitrile with a series of bis(aldehydes) containing ether linkages afforded the corresponding bis(2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbonitrile) derivatives in good to moderate yield. Oxidative aromatization of the latter compounds into the corresponding bis(2,6-dimethy...

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Veröffentlicht in:Monatshefte für Chemie 2016-07, Vol.147 (7), p.1227-1232
Hauptverfasser: Kassab, Refaie M., Elwahy, Ahmed H. M., Abdelhamid, Ismail Abdelshafy
Format: Artikel
Sprache:eng
Schlagworte:
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
Organic Chemistry
Original Paper
Physical Chemistry
Theoretical and Computational Chemistry
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Zusammenfassung:Reaction of β -aminocrotonitrile with a series of bis(aldehydes) containing ether linkages afforded the corresponding bis(2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbonitrile) derivatives in good to moderate yield. Oxidative aromatization of the latter compounds into the corresponding bis(2,6-dimethylpyridine-3,5-dicarbonitrile) derivatives was achieved using ceric ammonium nitrate (CAN). Graphical abstract
ISSN:0026-9247
1434-4475
DOI:10.1007/s00706-015-1644-z