Anti-inflammatory and analgesic effects of two new flavone C-glycosides from Panzeria alaschanica

Anti-inflammatory and analgesic effects of two new flavone C-glycosides from Panzeria alaschanica

Two new flavone C -glycosides, named as panzeroside A and B were isolated from the n -BuOH crude extract of the aerial parts of Panzeria alaschanica Kuprian. Their structures were elucidated by spectroscopic methods, including UV, IR, ESI–MS, 1D NMR, and 2D NMR techniques. Anti-inflammatory and anal...

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Veröffentlicht in:Monatshefte für Chemie 2015-06, Vol.146 (6), p.1025-1030
Hauptverfasser: Wang, Qinghu, Wu, Jiesi, Wu, Xiaolan, Tai, Wenquan, Dai, Nayintai, Wu, Rongjun, Han, Narenchaoketu
Format: Artikel
Sprache:eng
Schlagworte:
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
Organic Chemistry
Original Paper
Physical Chemistry
Theoretical and Computational Chemistry
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Zusammenfassung:Two new flavone C -glycosides, named as panzeroside A and B were isolated from the n -BuOH crude extract of the aerial parts of Panzeria alaschanica Kuprian. Their structures were elucidated by spectroscopic methods, including UV, IR, ESI–MS, 1D NMR, and 2D NMR techniques. Anti-inflammatory and analgesic activities of were assessed in rats by the hot plate test, paw pressure, and carrageenan-induced paw oedema. The two new compounds showed significant and dose-dependent analgesic and anti-inflammatory effects. Graphical abstract
ISSN:0026-9247
1434-4475
DOI:10.1007/s00706-015-1414-y