The chemoselective N-Boc protection of amines in the presence of solid-supported perchloric acid as an efficient and reusable solid acid

The chemoselective N -Boc protection of amines has been performed in the presence of catalytic amount of poly(4-vinylpyridinium) perchlorate at room temperature .and neat conditions. This new method has distinct advantages, including its excellent yields and short reaction times as well as being green in terms of avoiding the use of toxic catalysts and solvents. Furthermore, the catalyst can be reused and recycled several times without significant loss in its activity. Graphical abstract