A facile and improved synthesis of desomorphine and its deuterium-labeled analogue

A facile and improved synthesis of desomorphine and its deuterium-labeled analogue

This work describes a convenient and improved process for the synthesis of desomorphine from codeine. The proposed method affords the highly pure opiate without the aid of chromatographic purification, and provides a simple route for the synthesis of [ 2 H 3 ] deuterium-labeled desomorphine. Graphic...

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Veröffentlicht in:Monatshefte für Chemie 2012, Vol.143 (1), p.171-174
Hauptverfasser: Srimurugan, Sankareswaran, Su, Chi-Ju, Shu, Hun-Chi, Murugan, Kaliyappan, Chen, Chinpiao
Format: Artikel
Sprache:eng
Schlagworte:
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
Organic Chemistry
Original Paper
Physical Chemistry
Theoretical and Computational Chemistry
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Zusammenfassung:This work describes a convenient and improved process for the synthesis of desomorphine from codeine. The proposed method affords the highly pure opiate without the aid of chromatographic purification, and provides a simple route for the synthesis of [ 2 H 3 ] deuterium-labeled desomorphine. Graphical abstract
ISSN:0026-9247
1434-4475
DOI:10.1007/s00706-011-0635-y