Synthesis and biological activity of (Z) and (E) isomers of 3-(3,4-diaryl-1,2,4-triazole-5-yl)prop-2-enoic acid

Synthesis and biological activity of (Z) and (E) isomers of 3-(3,4-diaryl-1,2,4-triazole-5-yl)prop-2-enoic acid

( Z )-3-(3,4-diaryl-1,2,4-triazole-5-yl)prop-2-enoic acid derivatives were obtained in the course of the reaction of N 3 -substituted amidrazones with maleic anhydride, and isomerized into the ( E ) isomers by heating under reflux in acetic acid solution. The molecular structure of the compounds obt...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Monatshefte für Chemie 2009-04, Vol.140 (4), p.439-444
Hauptverfasser: Modzelewska-Banachiewicz, Bożena, Michalec, Barbara, Kamińska, Teresa, Mazur, Liliana, Kozioł, Anna E., Banachiewicz, Jacek, Ucherek, Marzena, Kandefer-Szerszeń, Martyna
Format: Artikel
Sprache:eng
Schlagworte:
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
Organic Chemistry
Original Paper
Physical Chemistry
Theoretical and Computational Chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:( Z )-3-(3,4-diaryl-1,2,4-triazole-5-yl)prop-2-enoic acid derivatives were obtained in the course of the reaction of N 3 -substituted amidrazones with maleic anhydride, and isomerized into the ( E ) isomers by heating under reflux in acetic acid solution. The molecular structure of the compounds obtained was confirmed by IR and 1 H NMR spectroscopy, and by X-ray crystallography for (2 E )-3-(4,5-diphenyl-4 H -1,2,4-triazol-3-yl)prop-2-enoic acid. The antiviral and immunomodulating activity of several of the compounds was examined. Graphical abstract
ISSN:0026-9247
1434-4475
DOI:10.1007/s00706-008-0055-9