Microwave-assisted synthesis and antimicrobial activity of 5-trihalomethyl-3-arylisoxazoles

Microwave-assisted synthesis and antimicrobial activity of 5-trihalomethyl-3-arylisoxazoles

A series of twelve 5-trihalomethyl-3-arylisoxazoles was synthesized and screened for antibacterial and antifungal activities. The compounds were synthesized from the cyclondensation of 1,1,1-trihalo-4-alkoxy-3-alken-2-ones [C X 3 C(O)C( R 2 )=C( R 1 )O R , where X = Cl and F; R = Me ; R 2 =H; R 1 =H...

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Veröffentlicht in:Monatshefte für Chemie 2008-08, Vol.139 (8), p.985-990
Hauptverfasser: Martins, Marcos A. P., Machado, Pablo, Piovesan, Luciana A., Flores, Alex F. C., de Campos, Marli M. A., Scheidt, Carolina, Bonacorso, Helio G., Zanatta, Nilo
Format: Artikel
Sprache:eng
Schlagworte:
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
Organic Chemistry
Physical Chemistry
Theoretical and Computational Chemistry
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Zusammenfassung:A series of twelve 5-trihalomethyl-3-arylisoxazoles was synthesized and screened for antibacterial and antifungal activities. The compounds were synthesized from the cyclondensation of 1,1,1-trihalo-4-alkoxy-3-alken-2-ones [C X 3 C(O)C( R 2 )=C( R 1 )O R , where X = Cl and F; R = Me ; R 2 =H; R 1 =H, Me , F, Cl, Br, and NO 2 ] with hydroxylamine hydrochloride through a rapid one-pot reaction via microwave irradiation. Some of the 5-trihalomethyl-3-arylisoxazoles exhibited good in vitro anti- Cryptococcus activity.
ISSN:0026-9247
1434-4475
DOI:10.1007/s00706-007-0849-1