Synthesis and cytotoxic activity of resveratrol-based compounds

In continuation of our studies on compounds with a resveratrol-based scaffold two compounds with N -containing functional groups have been synthesized and screened for their inhibitory effect on the growth of the human cancer cell lines HT29, 518A2, AsPC-1, BxPC-3, and PC-3. Compound 4 , but not 1 , demonstrated pronounced in vitro cytotoxicity against all these cancer cell lines, thus making this compound a promising candidate for further preclinical in vivo studies.