6-Hydroxydopamine: a far from simple neurotoxin

6-Hydroxydopamine (6-OHDA), which is a neurotoxin that selectively destroys catecholaminergic nerves in sympathetically innervated tissues, has been used to provide a model of Parkinson’s disease in experimental animals. It is rapidly autoxidised to yield potentially toxic products and reactive oxyg...

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Veröffentlicht in:Journal of Neural Transmission 2020-02, Vol.127 (2), p.213-230
Hauptverfasser: Varešlija, Damir, Tipton, Keith F., Davey, Gavin P., McDonald, Andrew G.
Format: Artikel
Sprache:eng
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Zusammenfassung:6-Hydroxydopamine (6-OHDA), which is a neurotoxin that selectively destroys catecholaminergic nerves in sympathetically innervated tissues, has been used to provide a model of Parkinson’s disease in experimental animals. It is rapidly autoxidised to yield potentially toxic products and reactive oxygen species. Its ability to release Fe(II) from protein storage sites also results in the formation of hROS. This account will consider how this family of toxic products may contribute to the observed effects of 6-OHDA.
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-019-02133-6