Virilizing mature ovarian cystic teratomas

Three further cases of mature benign cystic teratomas of the ovary associated with virilization are added to the three previously reported in the literature. They were found in postmenopausal, obese, diabetic women aged 52, 61, and 67 years. The patients presented with hirsutism and voice changes an...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Virchows Archiv : an international journal of pathology 1997-08, Vol.431 (2), p.149-151
Hauptverfasser: LOPEZ-BELTRAN, A, CALANAS, A. S, JIMENA, P, ESCUDERO, A. L, CAMPELLO, T. R, MUNOZ-TORRES, M, ESCOBAR-JIMENEZ, F, CARVIA, R. E, NOGALES, F. F
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Three further cases of mature benign cystic teratomas of the ovary associated with virilization are added to the three previously reported in the literature. They were found in postmenopausal, obese, diabetic women aged 52, 61, and 67 years. The patients presented with hirsutism and voice changes and clitoromegaly was present in one. Testosterone and androstenedione levels were elevated but promptly regressed after removal of the tumours. Histologically, sheets of stromal luteinized cells were found peripherally at the interface between the neoplasm and ovarian tissue. Luteinization of ovarian stroma induced by an unknown factor related to diabetes mellitus is the origin of the virilization.
ISSN:0945-6317
1432-2307
DOI:10.1007/s004280050081