The contribution of α1B-adrenoceptor subtype in the renal vasculature of fructose-fed Sprague–Dawley rats
Purpose Fructose feeding induces a moderate increase in blood pressure, insulin resistance, and hyperinsulinemia. This study investigated the role of α 1B -adrenoceptor subtype in the control of renal hemodynamic responses to exogenously administered angiotensin II (Ang II) and a set of adrenergic a...
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Veröffentlicht in: | European journal of nutrition 2011-06, Vol.50 (4), p.251-260 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
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Zusammenfassung: | Purpose
Fructose feeding induces a moderate increase in blood pressure, insulin resistance, and hyperinsulinemia. This study investigated the role of α
1B
-adrenoceptor subtype in the control of renal hemodynamic responses to exogenously administered angiotensin II (Ang II) and a set of adrenergic agonists in a model of high fructose-fed rats.
Methods
Sprague–Dawley rats were fed for 8 weeks with 20% fructose in drinking water (FFR). The renal cortical vasoconstriction to noradrenaline (NA), phenylephrine (PE), methoxamine (ME) and Ang II in the presence and absence of chloroethylclonidine (CEC) (α
1B
-adrenoceptor antagonist) was determined. Data, mean ± SEM or SD were subjected to ANOVA with significance at
p
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ISSN: | 1436-6207 1436-6215 |
DOI: | 10.1007/s00394-010-0133-8 |