Platelet biology and the rationale of PRP therapy in chronic wounds

For the past four decades, platelets have been thought to function only in hemostatic processes. With reference to recent research, today, it is known that platelets also play important roles in tissue regeneration and immunological processes. The keystone of the use of platelet-rich plasma (PRP) for the treatment of chronic wounds lays in the molecular composition of thrombocytes, which are rich in growth factors and other biologically active substances. PRP forms a matrix for cells and thus promotes wound healing processes. Harvesting PRP is relatively uncomplicated, minimally invasive, and potentially available for each patient. In this review, we provide an overview of the biology of the thrombocyte to better understand the effects of PRP. Additionally, we reviewed published studies, analyzing the effectiveness of PRP for the treatment of chronic wounds. Level of evidence: Not ratable.