Reversible posterior leukoencephalopathy after combination chemotherapy

We describe a young woman with Burkitt's lymphoma, treated with intravenous adriamycine and cyclophosphamide and intrathecal cytarabine. She developed a reversible posterior leukoencephalopathy syndrome (RPLS) with typical MRI findings. Diffusion-weighted images during the first days after the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroradiology 2000-12, Vol.42 (12), p.895-899
Hauptverfasser:	HONKANIEMI, J, KÄHÄRÄ, V, FREY, H, DASTIDAR, P, LATVALA, M, HIETAHARJU, A, SALONEN, T, KESKINEN, L, OLLIKAINEN, J, VÄHÄMÄKI, L, KELLOKUMPU-LEHTINEN, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Burkitt Lymphoma - drug therapy Cyclophosphamide - administration & dosage Cytarabine - administration & dosage Doxorubicin - administration & dosage Drug toxicity and drugs side effects treatment Female Humans Injections, Spinal Leukocytes Magnetic Resonance Imaging Medical sciences Neurotoxicity Syndromes - drug therapy Neurotoxicity Syndromes - etiology Neurotoxicity Syndromes - pathology Pharmacology. Drug treatments Steroids - therapeutic use Toxicity: nervous system and muscle
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We describe a young woman with Burkitt's lymphoma, treated with intravenous adriamycine and cyclophosphamide and intrathecal cytarabine. She developed a reversible posterior leukoencephalopathy syndrome (RPLS) with typical MRI findings. Diffusion-weighted images during the first days after the onset of symptoms predicted a small irreversible lesion in the frontal lobe, verified on T2-weighted images 1 month later. The patient showed full recovery after high-dose steroid treatment.
ISSN:	0028-3940 1432-1920
DOI:	10.1007/s002340000482