Effects of verbascoside biotechnologically produced by Syringa vulgaris plant cell cultures in a rodent model of colitis

The aim of the present study was to examine the effects of verbascoside (VB) in rats subjected to experimental colitis. Colitis was induced in rats by intracolonic instillation of 2,4 dinitrobenzene sulfonic acid (DNBS; 25 mg/rat). VB was administered daily per os (0.2 and 2 mg/kg) 4 days after DNBS...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2009-07, Vol.380 (1), p.79-94
Hauptverfasser:	Mazzon, Emanuela, Esposito, Emanuela, Di Paola, Rosanna, Riccardi, Luisa, Caminiti, Rocco, Dal Toso, Roberto, Pressi, Giovanna, Cuzzocrea, Salvatore
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - administration & dosage Antioxidants - isolation & purification Antioxidants - therapeutic use Biomedical and Life Sciences Biomedicine Body Weight - drug effects Cells, Cultured Colitis - drug therapy Colitis - physiopathology Disease Models, Animal Dose-Response Relationship, Drug Enzyme Precursors - drug effects Enzyme Precursors - metabolism Gelatinases - drug effects Gelatinases - metabolism Glucosides - administration & dosage Glucosides - isolation & purification Glucosides - therapeutic use Male Matrix Metalloproteinase 9 - drug effects Matrix Metalloproteinase 9 - metabolism Neurosciences Original Article Peroxidase - drug effects Peroxidase - metabolism Pharmacology/Toxicology Phenols - administration & dosage Phenols - isolation & purification Phenols - therapeutic use Rats Rats, Sprague-Dawley Syringa - chemistry Thiobarbituric Acid Reactive Substances - metabolism Transcription Factor RelA - drug effects Transcription Factor RelA - metabolism
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Beschreibung
Zusammenfassung:	The aim of the present study was to examine the effects of verbascoside (VB) in rats subjected to experimental colitis. Colitis was induced in rats by intracolonic instillation of 2,4 dinitrobenzene sulfonic acid (DNBS; 25 mg/rat). VB was administered daily per os (0.2 and 2 mg/kg) 4 days after DNBS administration in the colon. Treatment with VB significantly ( P
ISSN:	0028-1298 1432-1912
DOI:	10.1007/s00210-009-0400-5