Synthesis and biological evaluation of novel resveratrol-oxadiazole hybrid heterocycles as potential antiproliferative agents

Synthesis and biological evaluation of novel resveratrol-oxadiazole hybrid heterocycles as potential antiproliferative agents

A novel class of resveratrol-oxadiazole hybrid compounds was synthesized to screen for their in vitro antiproliferative activity against three human cancer cell lines. All the compounds showed superior antiproliferative activity than the reference compound resveratrol. The most promising active comp...

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Veröffentlicht in:Medicinal chemistry research 2016-04, Vol.25 (4), p.627-643
Hauptverfasser: Murty, M. S. R., Penthala, Raju, Polepalli, Sowjanya, Jain, N.
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
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Zusammenfassung:A novel class of resveratrol-oxadiazole hybrid compounds was synthesized to screen for their in vitro antiproliferative activity against three human cancer cell lines. All the compounds showed superior antiproliferative activity than the reference compound resveratrol. The most promising active compounds in this series were 1g , 2g , 1c , 2c , 2i and 1a (GI 50  
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-016-1514-1