Analgesic, anti-inflammatory and anti-pyretic activities of D-3-O-methylchiroinositol isolated from stem bark of Piliostigma thonningii

Analgesic, anti-inflammatory and anti-pyretic activities of D-3-O-methylchiroinositol isolated from stem bark of Piliostigma thonningii

D-3-O-methylchiroinositol isolated from the stem bark of Piliostigma thonningii was evaluated for analgesic, anti-inflammatory and anti-pyretic activities. The compound was screened for analgesic activity by the acetic acid-induced writhing and tail immersion tests. The anti-inflammatory activities...

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Veröffentlicht in:Medicinal chemistry research 2015-12, Vol.24 (12), p.4139-4145
Hauptverfasser: Nwaehujor, Chinaka O., Udegbunam, Rita I., Asuzu, Isaac U.
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
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Zusammenfassung:D-3-O-methylchiroinositol isolated from the stem bark of Piliostigma thonningii was evaluated for analgesic, anti-inflammatory and anti-pyretic activities. The compound was screened for analgesic activity by the acetic acid-induced writhing and tail immersion tests. The anti-inflammatory activities were evaluated by the carrageenan-induced paw edema and Freund adjuvant-induced arthritis tests, while its anti-pyretic activity was determined using the yeast-induced pyrexia test. D-3-O-methylchiroinositol (10, 30 and 60 mg/kg) significantly ( P  
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-015-1459-9