Novel malyngamide structural analogs: synthesis and biological evaluation

Novel malyngamide structural analogs: synthesis and biological evaluation

In the course of our search for new anticancer agents, a series of novel malyngamide derivatives were synthesized by sharpless asymmetric epoxidation, followed by Julia-Kocinski olefination reactions as key reaction sequence. Anticancer activities of all these derivatives were screened against IMR-3...

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Veröffentlicht in:Medicinal chemistry research 2013-10, Vol.22 (10), p.4581-4591
Hauptverfasser: Reddy, G. Venkateswar, Kumar, T. Vijaya, Siva, B., Babu, K. Suresh, Srinivas, P. V., Sehar, Irum, Saxena, A. K., Rao, J. Madhusudana
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
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Zusammenfassung:In the course of our search for new anticancer agents, a series of novel malyngamide derivatives were synthesized by sharpless asymmetric epoxidation, followed by Julia-Kocinski olefination reactions as key reaction sequence. Anticancer activities of all these derivatives were screened against IMR-32, SF-295, SKNSH, HeLa, Colon-502713, SW-620, and Hop-62 cell lines for the first time.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-013-0466-y