Synthesis of B-ring substituted flavones and evaluation of their antitumor and antioxidant activities

Synthesis of B-ring substituted flavones and evaluation of their antitumor and antioxidant activities

A series of flavones, substituted at the ring B, were synthesized using either Claisen–Schimdt Condensation or Baker–Venkataraman rearrangement. The synthesized compounds were tested for in vitro cytotoxic activity by sulforhodamine B assay against three cell lines of different origin, viz. HepG2, M...

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Veröffentlicht in:Medicinal chemistry research 2013-09, Vol.22 (9), p.4293-4299
Hauptverfasser: Joshi, Akshada J., Gadhwal, Manoj K., Joshi, Urmila J., D’Mello, Priscilla, Sinha, Ragini, Govil, Girjesh
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
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Zusammenfassung:A series of flavones, substituted at the ring B, were synthesized using either Claisen–Schimdt Condensation or Baker–Venkataraman rearrangement. The synthesized compounds were tested for in vitro cytotoxic activity by sulforhodamine B assay against three cell lines of different origin, viz. HepG2, MCF-7, and MOLT-4. The compounds were also tested for a possible antioxidant activity by determination of inhibition of lipid peroxidation. Quercetin was taken as a standard for antioxidant activity. Compound 1c showed the highest cytotoxic activity against MCF-7 (GI50 
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-012-0423-1