Synthesis of 2-[4,5-dimethyl-1-(phenylamino)-1H-imidazol-2-ylthio]-N-(thiazole-2-yl)acetamide derivatives and their anticancer activities

In this work, 2-(4,5-dimethyl-1-(phenylamino)-1 H -imidazol-2-ylthio)- N -(thiazol-2-yl) acetamide derivatives were synthesized by reacting 4,5-dimethyl-1-(phenylamino)-1 H -imidazole-2(3 H )-thione derivatives with some 2-chloro- N -(thiazol-2-yl)acetamide compounds. The structure of synthesized compounds was confirmed by IR, 1 H NMR, and mass spectra. Anticancer activities of the compounds selected by the National Cancer Institute were investigated by testing against a panel of 60 different human tumor cell lines derived from nine neoplastic cancer types. Compounds 7 , 13 , and 23 exhibited reasonable anticancer activity against the screened cancer types with relatively low GI 50 values. The compounds showed high activity against melanoma-type cell lines.