Synthesis of some novel 1,2,4-triazole and 1,3,4-oxadiazole derivatives of biological interest

In this study, a series of novel [1,2,4]-triazolo-[1,3,4]oxadiazole ( 8 ), [1,2,4]-triazolo-[1,3,4]oxadiazole thioethers ( 9a – b ), [1,2,4]-triazolo-[1,3,4]oxadiazole arylidines ( 10a – g ), and bis[1,2,4]-triazole ( 11 ) derivatives were prepared with the objective of developing better antimicrobial activity. The structures of the compounds were elucidated by spectral analysis. The newly synthesized compounds ( 8 ), ( 9a – b ), ( 10a – g ), and ( 11 ) were screened for their antimicrobial activity. Among all the tested compounds ( 10b ) shows significant antibacterial activity.