Acute and chronic anti-inflammatory evaluation of imidazo[1,2-a]pyridine carboxylic acid derivatives and docking analysis

A docking analysis performed on four selected imidazo[1,2- a ]pyridine carboxylic acid derivatives indicated the binding of these to enzymes COX-1 and COX-2 active pockets. An in vitro analysis showed that compound 3-amino imidazo[1,2- a ]pyridine-2-carboxylic acid ( 5 ) preferentially inhibited COX-2. The compounds (10 mg/kg) were evaluated in relation to a potential acute and chronic anti-inflammatory activity. Compound ( 5 ) and imidazo[1,2- a ]pyridine-2-carboxylic acid ( 2 ) inhibited the edema produced by carrageenan more efficiently than indomethacin. Chronic anti-inflammatory activity was found in derivative ( 5 ) and indomethacin-treated groups in the granuloma model, the compound ( 2 ) and nitro-acid ( 4 ) had only a fair activity. Compound ( 2 ), nitro-carboxylate ( 3 ), and ( 5 ) did not produce gastroduodenal damage.