Synthesis and evaluation of substituted 5-(3-chloro-2-oxo-4-phenylazetidin-1-ylamino)pyrimidine-2,4,6(1H,3H,5H)-triones against pentylenetetrazole-induced convulsant in mice

This study was designed to synthesis of substituted 5-(3-chloro-2-oxo-4-phenylazetidin-1-ylamino)pyrimidine-2,4,6(1 H ,3 H ,5 H )-triones followed by evaluation against pentylenetetrazole-(PTZ) induced convulsant in mice. The titled compounds were confirmed by IR and 1 H-NMR spectral techniques. Pre-treatment of compound 4c showed significant anticonvulsant activity at 40 mg/kg which was comparable to that of PTZ and sodium valproate pre-treated groups. The results show the importance of barbituric acid derivative (i.e., compound 4c (R = p -OH, m -OCH 3 ) for this anti-convulsant activity. It may be due to its anti-oxidative and neuroprotective potential. Therefore, compound 4c emerged as the most active molecules in the management of convulsive disorder.