Design, synthesis, and anticonvulsant activity of novel quinazolinone analogues

Design, synthesis, and anticonvulsant activity of novel quinazolinone analogues

A number of 2-substituted and 2,3-disubstituted quinazolinone analogues have been synthesized. Their structures have been elucidated on the basis of elemental analyses and spectroscopic studies (IR, 1 H NMR, and MS). An evaluation of the anticonvulsant activity of the prepared compounds has indicate...

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Veröffentlicht in:Medicinal chemistry research 2011-11, Vol.20 (8), p.1280-1286
Hauptverfasser: Abdel Gawad, Nagwa M., Georgey, Hanan Hanna, Youssef, Riham M., El Sayed, Nehad A.
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
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Zusammenfassung:A number of 2-substituted and 2,3-disubstituted quinazolinone analogues have been synthesized. Their structures have been elucidated on the basis of elemental analyses and spectroscopic studies (IR, 1 H NMR, and MS). An evaluation of the anticonvulsant activity of the prepared compounds has indicated that some of them exhibit moderate to significant activity, compared to diazepam and phenobarbital standards.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-010-9465-4