Insulinotropic activity of chromonyl-2,4-thiazolidinediones

Insulinotropic activity of chromonyl-2,4-thiazolidinediones

Numerous compounds have been prepared in order to improve the pharmacological profile of insulinotropic activities. In the present paper, series of chromonyl-2,4-thiazolidinediones (Ia-e, IIa-e, and IIIa-e) were tested for their insulinotropic activities in INS-1 cells. Compounds IIb-d and IIId were...

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Veröffentlicht in:Medicinal chemistry research 2009, Vol.18 (8), p.665-670
Hauptverfasser: Verspohl, Eugen J, Bozdağ-Dündar, Oya, Kaup, Rebecca M, Bauer, Katrin, Ertan, Rahmiye
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
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Zusammenfassung:Numerous compounds have been prepared in order to improve the pharmacological profile of insulinotropic activities. In the present paper, series of chromonyl-2,4-thiazolidinediones (Ia-e, IIa-e, and IIIa-e) were tested for their insulinotropic activities in INS-1 cells. Compounds IIb-d and IIId were very active even at a low concentration of 0.001 mg/ml. Compounds IIIa-c were active only at higher concentration (0.01 mg/ml). Increase of insulin release was observed in the presence of 5.6 mmol/l glucose.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-008-9158-4