Effect of gold nanoparticles on the respiratory activity of peritoneal macrophages
This work was undertaken to investigate the effect of antigen-conjugated gold nanoparticles on the functional activity of cells of the reticuloendothelial system. Experiments using rat and mouse peritoneal cells assessed the dynamics of the total respiratory activity of macrophages and the activity...
Gespeichert in:
Veröffentlicht in: | Gold Bulletin 2009-01, Vol.42 (2), p.153-156 |
---|---|
Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | This work was undertaken to investigate the effect of antigen-conjugated gold nanoparticles on the functional activity of cells of the reticuloendothelial system. Experiments using rat and mouse peritoneal cells assessed the dynamics of the total respiratory activity of macrophages and the activity of mitochondrial dehydrogenases on exposure to colloidal gold conjugates of high- and lowmolecular-weight antigens. Both gold nanoparticles and their antigen conjugates stimulated the respiratory activity of the macrophages and the activity of macrophage mitochondrial enzymes. This stimulation may be an essential factor determining the adjuvant properties of colloidal gold, found by us in prior work. |
---|---|
ISSN: | 0017-1557 2190-7579 |
DOI: | 10.1007/BF03214925 |