The effect of food and metoclopramide on the pharmacokinetics and side effects of bromocriptine
The effect of food and metoclopramide on the pharmacokinetics of bromocriptine was investigated in 7 healthy subjects. Plasma concentrations of bromocriptine were measured by radioimmunoassay after a single oral dose of 7.5 mg bromocriptine. Maximal plasma concentrations of bromocriptine were slight...
Gespeichert in:
| Veröffentlicht in: | European journal of drug metabolism and pharmacokinetics 1991-07, Vol.16 (3), p.177-181 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 181 |
|---|---|
| container_issue | 3 |
| container_start_page | 177 |
| container_title | European journal of drug metabolism and pharmacokinetics |
| container_volume | 16 |
| creator | KOPITAR, Z VRHOVAC, B LOVSIC, L PLAVSIC, F FRANCETIC, I URBANCIC, J |
| description | The effect of food and metoclopramide on the pharmacokinetics of bromocriptine was investigated in 7 healthy subjects. Plasma concentrations of bromocriptine were measured by radioimmunoassay after a single oral dose of 7.5 mg bromocriptine. Maximal plasma concentrations of bromocriptine were slightly lower when the drug was given after breakfast. Bioavailability of the drug was not significantly reduced by food nor by metoclopramide pre-treatment. Side effects of bromocriptine were considerably reduced by metoclopramide pre-treatment (0.5 mg/kg); the decrease was about 83% as estimated from Table II. |
| doi_str_mv | 10.1007/bf03189956 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1007_BF03189956</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1814735</sourcerecordid><originalsourceid>FETCH-LOGICAL-c377t-1c4a6c5277dea2b24110860aec444beff29295e0669b6e6bf4e95cd4467febb23</originalsourceid><addsrcrecordid>eNpF0DtPwzAUBWALgUpVurAjeWBCCvjteISKAlIlljJHtnOtBpo4ssPAvyclBe5yh_PpDAehS0puKSH6zgXCaWmMVCdozijRBaElOUVzwnVZaKPUOVrm_E7G46WRUs3QjJZUaC7nqNruAEMI4AccAw4x1th2NW5hiH4f-2TbpgYcOzyMsN_Z1FofP5oOhsbnH5oPYKrIhw6XYht9avphVBfoLNh9huXxL9Db-nG7ei42r08vq_tN4bnWQ0G9sMpLpnUNljkmKCWlIha8EMKN5cwwI4EoZZwC5YIAI30thNIBnGN8gW6mXp9izglC1aemtemroqQ67FQ9rH93GvHVhPtP10L9T6dVxvz6mNvs7T4k2_km_zFJFGOc8G88l2_1</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The effect of food and metoclopramide on the pharmacokinetics and side effects of bromocriptine</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>KOPITAR, Z ; VRHOVAC, B ; LOVSIC, L ; PLAVSIC, F ; FRANCETIC, I ; URBANCIC, J</creator><creatorcontrib>KOPITAR, Z ; VRHOVAC, B ; LOVSIC, L ; PLAVSIC, F ; FRANCETIC, I ; URBANCIC, J</creatorcontrib><description>The effect of food and metoclopramide on the pharmacokinetics of bromocriptine was investigated in 7 healthy subjects. Plasma concentrations of bromocriptine were measured by radioimmunoassay after a single oral dose of 7.5 mg bromocriptine. Maximal plasma concentrations of bromocriptine were slightly lower when the drug was given after breakfast. Bioavailability of the drug was not significantly reduced by food nor by metoclopramide pre-treatment. Side effects of bromocriptine were considerably reduced by metoclopramide pre-treatment (0.5 mg/kg); the decrease was about 83% as estimated from Table II.</description><identifier>ISSN: 0378-7966</identifier><identifier>EISSN: 2107-0180</identifier><identifier>DOI: 10.1007/bf03189956</identifier><identifier>PMID: 1814735</identifier><language>eng</language><publisher>Genève: Médecine et hygiène</publisher><subject>Administration, Oral ; Adult ; Biological and medical sciences ; Biological Availability ; Bromocriptine - administration & dosage ; Bromocriptine - adverse effects ; Bromocriptine - blood ; Bromocriptine - pharmacokinetics ; Catecholaminergic system ; Food ; Humans ; Male ; Medical sciences ; Metoclopramide - pharmacology ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; Pharmacology. Drug treatments ; Radioimmunoassay</subject><ispartof>European journal of drug metabolism and pharmacokinetics, 1991-07, Vol.16 (3), p.177-181</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-1c4a6c5277dea2b24110860aec444beff29295e0669b6e6bf4e95cd4467febb23</citedby><cites>FETCH-LOGICAL-c377t-1c4a6c5277dea2b24110860aec444beff29295e0669b6e6bf4e95cd4467febb23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5062230$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1814735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KOPITAR, Z</creatorcontrib><creatorcontrib>VRHOVAC, B</creatorcontrib><creatorcontrib>LOVSIC, L</creatorcontrib><creatorcontrib>PLAVSIC, F</creatorcontrib><creatorcontrib>FRANCETIC, I</creatorcontrib><creatorcontrib>URBANCIC, J</creatorcontrib><title>The effect of food and metoclopramide on the pharmacokinetics and side effects of bromocriptine</title><title>European journal of drug metabolism and pharmacokinetics</title><addtitle>Eur J Drug Metab Pharmacokinet</addtitle><description>The effect of food and metoclopramide on the pharmacokinetics of bromocriptine was investigated in 7 healthy subjects. Plasma concentrations of bromocriptine were measured by radioimmunoassay after a single oral dose of 7.5 mg bromocriptine. Maximal plasma concentrations of bromocriptine were slightly lower when the drug was given after breakfast. Bioavailability of the drug was not significantly reduced by food nor by metoclopramide pre-treatment. Side effects of bromocriptine were considerably reduced by metoclopramide pre-treatment (0.5 mg/kg); the decrease was about 83% as estimated from Table II.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Bromocriptine - administration & dosage</subject><subject>Bromocriptine - adverse effects</subject><subject>Bromocriptine - blood</subject><subject>Bromocriptine - pharmacokinetics</subject><subject>Catecholaminergic system</subject><subject>Food</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metoclopramide - pharmacology</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Pharmacology. Drug treatments</subject><subject>Radioimmunoassay</subject><issn>0378-7966</issn><issn>2107-0180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0DtPwzAUBWALgUpVurAjeWBCCvjteISKAlIlljJHtnOtBpo4ssPAvyclBe5yh_PpDAehS0puKSH6zgXCaWmMVCdozijRBaElOUVzwnVZaKPUOVrm_E7G46WRUs3QjJZUaC7nqNruAEMI4AccAw4x1th2NW5hiH4f-2TbpgYcOzyMsN_Z1FofP5oOhsbnH5oPYKrIhw6XYht9avphVBfoLNh9huXxL9Db-nG7ei42r08vq_tN4bnWQ0G9sMpLpnUNljkmKCWlIha8EMKN5cwwI4EoZZwC5YIAI30thNIBnGN8gW6mXp9izglC1aemtemroqQ67FQ9rH93GvHVhPtP10L9T6dVxvz6mNvs7T4k2_km_zFJFGOc8G88l2_1</recordid><startdate>19910701</startdate><enddate>19910701</enddate><creator>KOPITAR, Z</creator><creator>VRHOVAC, B</creator><creator>LOVSIC, L</creator><creator>PLAVSIC, F</creator><creator>FRANCETIC, I</creator><creator>URBANCIC, J</creator><general>Médecine et hygiène</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19910701</creationdate><title>The effect of food and metoclopramide on the pharmacokinetics and side effects of bromocriptine</title><author>KOPITAR, Z ; VRHOVAC, B ; LOVSIC, L ; PLAVSIC, F ; FRANCETIC, I ; URBANCIC, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-1c4a6c5277dea2b24110860aec444beff29295e0669b6e6bf4e95cd4467febb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Bromocriptine - administration & dosage</topic><topic>Bromocriptine - adverse effects</topic><topic>Bromocriptine - blood</topic><topic>Bromocriptine - pharmacokinetics</topic><topic>Catecholaminergic system</topic><topic>Food</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metoclopramide - pharmacology</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Pharmacology. Drug treatments</topic><topic>Radioimmunoassay</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOPITAR, Z</creatorcontrib><creatorcontrib>VRHOVAC, B</creatorcontrib><creatorcontrib>LOVSIC, L</creatorcontrib><creatorcontrib>PLAVSIC, F</creatorcontrib><creatorcontrib>FRANCETIC, I</creatorcontrib><creatorcontrib>URBANCIC, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of drug metabolism and pharmacokinetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KOPITAR, Z</au><au>VRHOVAC, B</au><au>LOVSIC, L</au><au>PLAVSIC, F</au><au>FRANCETIC, I</au><au>URBANCIC, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of food and metoclopramide on the pharmacokinetics and side effects of bromocriptine</atitle><jtitle>European journal of drug metabolism and pharmacokinetics</jtitle><addtitle>Eur J Drug Metab Pharmacokinet</addtitle><date>1991-07-01</date><risdate>1991</risdate><volume>16</volume><issue>3</issue><spage>177</spage><epage>181</epage><pages>177-181</pages><issn>0378-7966</issn><eissn>2107-0180</eissn><abstract>The effect of food and metoclopramide on the pharmacokinetics of bromocriptine was investigated in 7 healthy subjects. Plasma concentrations of bromocriptine were measured by radioimmunoassay after a single oral dose of 7.5 mg bromocriptine. Maximal plasma concentrations of bromocriptine were slightly lower when the drug was given after breakfast. Bioavailability of the drug was not significantly reduced by food nor by metoclopramide pre-treatment. Side effects of bromocriptine were considerably reduced by metoclopramide pre-treatment (0.5 mg/kg); the decrease was about 83% as estimated from Table II.</abstract><cop>Genève</cop><pub>Médecine et hygiène</pub><pmid>1814735</pmid><doi>10.1007/bf03189956</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-7966 |
| ispartof | European journal of drug metabolism and pharmacokinetics, 1991-07, Vol.16 (3), p.177-181 |
| issn | 0378-7966 2107-0180 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF03189956 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Administration, Oral Adult Biological and medical sciences Biological Availability Bromocriptine - administration & dosage Bromocriptine - adverse effects Bromocriptine - blood Bromocriptine - pharmacokinetics Catecholaminergic system Food Humans Male Medical sciences Metoclopramide - pharmacology Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Radioimmunoassay |
| title | The effect of food and metoclopramide on the pharmacokinetics and side effects of bromocriptine |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T08%3A13%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20effect%20of%20food%20and%20metoclopramide%20on%20the%20pharmacokinetics%20and%20side%20effects%20of%20bromocriptine&rft.jtitle=European%20journal%20of%20drug%20metabolism%20and%20pharmacokinetics&rft.au=KOPITAR,%20Z&rft.date=1991-07-01&rft.volume=16&rft.issue=3&rft.spage=177&rft.epage=181&rft.pages=177-181&rft.issn=0378-7966&rft.eissn=2107-0180&rft_id=info:doi/10.1007/bf03189956&rft_dat=%3Cpubmed_cross%3E1814735%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/1814735&rfr_iscdi=true |