Cytotoxicity of urushiols isolated from sap of Korean lacquer tree (Rhus vernicifera Stokes)

Cytotoxicity of urushiols isolated from sap of Korean lacquer tree (Rhus vernicifera Stokes)

Cytotoxicities of four urushiols, congeners isolated from the sap of Korean lacquer tree (Rhus vernicifera Stokes), to 29 human cancer cell lines originated from 9 organs were evaluated. Their values of 50% growth inhibition were below 4 microg/ml, and showed cell line specific cytotoxicity. The pre...

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Veröffentlicht in:Archives of pharmacal research 1999-12, Vol.22 (6), p.638-641
Hauptverfasser: Hong, D H, Han, S B, Lee, C W, Park, S H, Jeon, Y J, Kim, M J, Kwak, S S, Kim, H M
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic Agents - pharmacology
Catechols - pharmacology
Humans
Korea
Plant Extracts
Plants, Toxic
Toxicodendron - chemistry
Tumor Cells, Cultured
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Zusammenfassung:Cytotoxicities of four urushiols, congeners isolated from the sap of Korean lacquer tree (Rhus vernicifera Stokes), to 29 human cancer cell lines originated from 9 organs were evaluated. Their values of 50% growth inhibition were below 4 microg/ml, and showed cell line specific cytotoxicity. The present result is the first report on the cytotoxicity of urushiols suggesting that they would have an anticancer activity to human cancer cells.
ISSN:0253-6269
1976-3786
DOI:10.1007/bf02975339