Safety evaluation and biochemical behavior of monotertiarybutylhydroquinone [Oil-soluble food grade antioxidant]

The safety of monotertiarybutylhydroquinone as an oil‐soluble food grade antioxidant was evaluated in acute studies with rats and dogs, in subacute feedings in rats, in rat reproductive efficiency and placental transfer studies, and in subacute feedings with monotertiarybutylhydroquinone heated in vegetable oil. In lifetime feedings in rats and 2 year feedings in dogs, wt gain, feed consumption, behavior, mortality, hemograms, clinical chemistries, gross, microscopic, and electron microscopy were evaluated. There were no toxic or untoward effects. Monotertiarybutylhydroquinone was handled similarly by rats, dogs, and humans. Rats eliminated single oral 0.1–0.4 g/kg doses mostly in the urine in 3–4 days as the 4‐0‐sulfate (57–80%) and the 4‐0‐glucuronide (4%) and with 4–12% unchanged. 2,3,5,6‐14C‐Monotertiarybutylhydroquinone was eliminated similarly with