Neurotoxicity of immunotoxins

Immunotoxins are being tested for the therapy of systemic cancer and brain tumors. Neurotoxicity has been dose limiting for several of these antibody conjugates given systemically. We review the animal and clinical data related to the neurotoxicity of immunotoxins in attempt to understand the molecu...

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Veröffentlicht in:	Molecular and chemical neuropathology 1994-02, Vol.21 (2-3), p.379-386
Hauptverfasser:	Ilercil, O, Laske, D W, Walbridge, S, Muaszko, K, Oldfield, E H, Youle, R J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Neoplasms - therapy Central Nervous System - drug effects Central Nervous System - pathology Clinical Trials as Topic Female Humans Immunotoxins - therapeutic use Immunotoxins - toxicity Neoplasms - therapy Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:	Immunotoxins are being tested for the therapy of systemic cancer and brain tumors. Neurotoxicity has been dose limiting for several of these antibody conjugates given systemically. We review the animal and clinical data related to the neurotoxicity of immunotoxins in attempt to understand the molecular basis for the unexpected neural involvement and to prevent or minimize this toxicity in future clinical trials.
ISSN:	1044-7393
DOI:	10.1007/BF02815363