Cholera Toxin Stimulation of Human Mammary Epithelial Cells in Culture

Cholera Toxin Stimulation of Human Mammary Epithelial Cells in Culture

Addition of cholera toxin to human mammary epithelial cultures derived from reduction mammoplasties and primary carcinomas greatly stimulated cell growth and increased the number of times the cells could be successfully subcultured. Other agents known to increase intracellular cAMP levels were also...

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Veröffentlicht in:In Vitro 1982-06, Vol.18 (6), p.531-537
1. Verfasser: Stampeer, Martha R.
Format: Artikel
Sprache:eng
Schlagworte:
550300 - Cytology
ANIMAL CELLS
ANTIGENS
BACTERIAL DISEASES
BASIC BIOLOGICAL SCIENCES
BIOLOGICAL EFFECTS
BODY
Breast - cytology
Breast - drug effects
Breast - metabolism
Breast Neoplasms - pathology
Cell Division - drug effects
Cell growth
Cell lines
CELL PROLIFERATION
Cells, Cultured
CHOLERA
Cholera Toxin - pharmacology
Cultured cells
Cyclic AMP - metabolism
DISEASES
Epidermal cells
Epithelial Cells
Epithelium - drug effects
Epithelium - metabolism
Female
GLANDS
Humans
IN VITRO
INFECTIOUS DISEASES
Mammaplasty
MAMMARY GLANDS
MATERIALS
ORGANS
Seeding
Specimens
STIMULATION
TOXIC MATERIALS
TOXINS
TUMOR CELLS
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Beschreibung
Zusammenfassung:Addition of cholera toxin to human mammary epithelial cultures derived from reduction mammoplasties and primary carcinomas greatly stimulated cell growth and increased the number of times the cells could be successfully subcultured. Other agents known to increase intracellular cAMP levels were also growth stimulatory. The increased growth potential conferred by cholera toxin enhances the usefulness of this cell culture system.
ISSN:0073-5655
1475-2689
DOI:10.1007/BF02810076