The effect of toxic doses of cholecalciferol (vitamin D3) on the serum zinc levels in rats

Zinc is a trace element important to bone mineralization as well as, in general, nutrition. It is known that cholecalciferol (vitamin D3) affects bone metabolism. In this study, toxic doses of vitamin D3 were injected subcutaneously (25 micrograms/d) to rats for 5 wk. It caused a significant increas...

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Veröffentlicht in:	Biological trace element research 1993-04, Vol.37 (1), p.85-89
Hauptverfasser:	Guven, Y. (Istanbul University, Istanbul, Turkey), Yildirim, S, Kasapoglu, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - blood Animals Biological and medical sciences BLOOD SERUM Bone Diseases, Metabolic - blood Bone Diseases, Metabolic - chemically induced Calcium - blood Cholecalciferol - poisoning CINC DIET DIETA Drug intoxications. Doping Male Medical sciences NUTRIENT EXCESSES NUTRIENTES NUTRIENTS Pharmacology. Drug treatments RAT RATA RATS Rats, Wistar REGIME ALIMENTAIRE SERUM SANGUIN SUBSTANCE NUTRITIVE SUERO SANGUINEO TOXICIDAD TOXICITE TOXICITY VITAMIN D VITAMINA D VITAMINE D ZINC Zinc - blood
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Beschreibung
Zusammenfassung:	Zinc is a trace element important to bone mineralization as well as, in general, nutrition. It is known that cholecalciferol (vitamin D3) affects bone metabolism. In this study, toxic doses of vitamin D3 were injected subcutaneously (25 micrograms/d) to rats for 5 wk. It caused a significant increase in serum zinc levels (p < 0.02). On the other hand, no significant increase was detected in the other groups. Excessive amounts of vitamin D3 caused bone breakdown and increased the levels of zinc in blood.
ISSN:	0163-4984 1559-0720
DOI:	10.1007/BF02789403