Modifying effect of iron on lead-induced clastogenicity in mouse bone marrow cells

Essential trace elements such as iron (Fe) are known to interact with nonessential metals like lead (Pb), influencing its metabolism. Ferric chloride and lead nitrate were administered intraperitoneally to Swiss albino mice Mus musculus singly and successively, with or without a time gap of 1 h, to...

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Veröffentlicht in:	Biological trace element research 1992-09, Vol.34 (3), p.279-286
Hauptverfasser:	HAIMANTI DHIR, SHARMA, A, TALUKDER, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bone Marrow - drug effects Bone Marrow Cells Chemical and industrial products toxicology. Toxic occupational diseases Chlorides Chromosome Aberrations Drug Interactions Ferric Compounds - administration & dosage Ferric Compounds - pharmacology Injections, Intraperitoneal Lead - administration & dosage Lead - toxicity Medical sciences Metals and various inorganic compounds Mice Nitrates - administration & dosage Nitrates - toxicity Toxicology
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Beschreibung
Zusammenfassung:	Essential trace elements such as iron (Fe) are known to interact with nonessential metals like lead (Pb), influencing its metabolism. Ferric chloride and lead nitrate were administered intraperitoneally to Swiss albino mice Mus musculus singly and successively, with or without a time gap of 1 h, to study the degree of protection, if any, afforded by iron against the clastogenic effects induced by Pb in bone marrow cells. A decrease in the frequency of lead-induced chromosomal aberrations was observed when Fe was given together with or prior to Pb administration.
ISSN:	0163-4984 1559-0720
DOI:	10.1007/BF02783683