Noradrenaline turnover in the tissues of uraemic rats

In female Wistar rats with acute renal failure a decrease of noradrenaline concentration in the heart, spleen and kidney was ascertained. Noradrenaline concentration after alpha-methyl-p-tyrosine and 6-hydroxydopamine in the heart, spleen and kidney was significantly lower than in the control group....

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Veröffentlicht in:	International urology and nephrology 1990, Vol.22 (1), p.89-93
Hauptverfasser:	Ksiazek, A, Solski, J
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Methyltyrosine Animals Catecholamines - metabolism Female Hydroxydopamines - pharmacology Kidney - metabolism Methyltyrosines - pharmacology Myocardium - metabolism Norepinephrine - metabolism Oxidopamine Rats Rats, Inbred Strains Spleen - metabolism Uremia - metabolism
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Beschreibung
Zusammenfassung:	In female Wistar rats with acute renal failure a decrease of noradrenaline concentration in the heart, spleen and kidney was ascertained. Noradrenaline concentration after alpha-methyl-p-tyrosine and 6-hydroxydopamine in the heart, spleen and kidney was significantly lower than in the control group. In the adrenals a decrease of catecholamine level after alpha-methyl-p-tyrosine and 6-hydroxydopamine has been noted in the controls. The changes in tissue noradrenaline concentration are evidence of a dysfunction in the adrenergic nervous system in uraemic rats.
ISSN:	0301-1623 1573-2584
DOI:	10.1007/BF02550441