Molecular mechanisms of endotoxin activity

Endotoxin (lipopolysaccharide, LPS), a constituent of the outer membrane of the cell wall of gram-negative bacteria, exerts a wide variety of biological effects in humans. This review focuses on the molecular mechanisms underlying these activities and discusses structure-function relationships of th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Archives of microbiology 1995-12, Vol.164 (6), p.383-389
Hauptverfasser:	SCHLETTER, J, HEINE, H, ULMER, A. J, RIETSCHEL, E. T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteriology Biological and medical sciences Carbohydrate Sequence Endotoxins - chemistry Endotoxins - toxicity Fundamental and applied biological sciences. Psychology Humans Lipid A - chemistry Lipid A - toxicity Lipopolysaccharide Receptors - metabolism Lipopolysaccharides - chemistry Lipopolysaccharides - metabolism Lipopolysaccharides - toxicity Membrane Proteins - metabolism Microbiology Molecular Sequence Data Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Shock, Septic - etiology Signal Transduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Endotoxin (lipopolysaccharide, LPS), a constituent of the outer membrane of the cell wall of gram-negative bacteria, exerts a wide variety of biological effects in humans. This review focuses on the molecular mechanisms underlying these activities and discusses structure-function relationships of the endotoxin molecule, its interaction with humoral and cellular receptors involved in cell activation, and transmembrane and intracellular signal transduction pathways.
ISSN:	0302-8933 1432-072X
DOI:	10.1007/BF02529735