Influence on erythropoietin levels of treatment with cisplatinum-endoxan

Erythropoietin levels have been determined in 24 patients with different gynecologic malignancies, who were treated with cisplatinum and endoxan. A statistically highly significant decrease was demonstrated 2 h after starting treatment with a further significant decrease at 6 h. After 12 h the eryth...

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Veröffentlicht in:	Archives of gynecology and obstetrics 1992-09, Vol.252 (1), p.49-53
Hauptverfasser:	Lechner, W, Artner-Dworzak, E, Sölder, E, Sachsenmaier, M, Kölle, D, Moncayo, H, Reitsamer, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cisplatin - administration & dosage Cisplatin - adverse effects Cyclophosphamide - administration & dosage Cyclophosphamide - adverse effects Erythropoietin - blood Female Genital Neoplasms, Female - blood Genital Neoplasms, Female - drug therapy Humans Middle Aged
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Zusammenfassung:	Erythropoietin levels have been determined in 24 patients with different gynecologic malignancies, who were treated with cisplatinum and endoxan. A statistically highly significant decrease was demonstrated 2 h after starting treatment with a further significant decrease at 6 h. After 12 h the erythropoietin concentrations returned to values similar to those before treatment started.
ISSN:	0932-0067 1432-0711
DOI:	10.1007/BF02389607