Amyotrophic lateral sclerosis: thyroid and prolactin hormone changes in thyrotropin-releasing hormone therapy

13 patients with amyotrophic lateral sclerosis (ALS) were treated with intravenous infusion of thyrotropin-releasing hormone (TRH). In 6 patients 2 mg/day of TRH was i.v. given over 2 hours for 10 days. In 7 others 2 mg/day of TRH was continuously infused by means of a pump. An increase of thyroid h...

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Veröffentlicht in:	Italian journal of neurological sciences 1990-12, Vol.11 (6), p.601-603
Hauptverfasser:	Testa, D, Chiodini, P G, Girotti, F, Attanasio, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic Lateral Sclerosis - blood Amyotrophic Lateral Sclerosis - drug therapy Amyotrophic Lateral Sclerosis - physiopathology Female Growth Hormone-Releasing Hormone - pharmacology Humans Male Middle Aged Prolactin - blood Prolactin - secretion Secretory Rate - drug effects Stimulation, Chemical Thyrotropin-Releasing Hormone - pharmacology Thyrotropin-Releasing Hormone - therapeutic use Thyroxine - blood Thyroxine - secretion Triiodothyronine - blood Triiodothyronine - secretion
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Zusammenfassung:	13 patients with amyotrophic lateral sclerosis (ALS) were treated with intravenous infusion of thyrotropin-releasing hormone (TRH). In 6 patients 2 mg/day of TRH was i.v. given over 2 hours for 10 days. In 7 others 2 mg/day of TRH was continuously infused by means of a pump. An increase of thyroid hormones related to the duration of the treatment was observed. A surprising finding was the onset of prolactin (PRL) response to growth hormone releasing hormone (GHRH), previously absent.
ISSN:	0392-0461 1590-3478
DOI:	10.1007/BF02337445